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Beyond diabetes, semaglutide is gaining fame for its weight loss benefits

Tirzepatide often leads to faster results for many patients, but both medications are extremely effective

Adding GLP-1 therapy after weight loss surgery requires careful medical evaluation, as the combination addresses weight loss through different mechanismssurgery reduces stomach capacity while semaglutide signals fullness in the brain

It uses the GLP-1/GIP dual incretin backbone (the same MAR709 chassis behind tirzepatide) instead of GLP-1 alone, which expands the targeted-cell population to include cells that express GIPR (most importantly, mature adipocytes)

Diabetes Care (1992) 15:2706